CATH Superfamily, Code:2.40.10.10, Name:Trypsin-like serine proteases

There are 43915 assignments for this superfamily in Gene3D.

Gene3D assignmnets for this domain have an average length of 94 amino acids

There are 3 Funfam(s) Funfams are sub-divisions of CATH superfamilies into functionally coherent sets for this superfamily

The superfamily is found in 1177 unique domain organisation(s) (architectures) A domain organisation or domain architecture, referrs to the specific sequence of domains in a protein. For discontiguous domains we have used the center of mass of the domain.

The superfamily has the following counts of taxons in the main branches of life: Viruses (2334) Archaea (116) Bacteria (7857) Eukaryotes (4720)

There are 21 OMIM entries identified in this superfamily

FunFam code	Name	Last common ancestor	Total sequences	Specific GO terms assigned
FF_2.40.10.10_37755	Serine protease -like domain 1	Viruses/Bacteria/Eukaryota	17654	serine-type endopeptidase activity, cysteine-type peptidase activity, isomerase activity,
FF_2.40.10.10_37754	Serine protease -like domain 2/3	Viruses/Bacteria/Eukaryota	35490	serine-type endopeptidase activity, isomerase activity, receptor signaling protein activity, threonine-type endopeptidase activity, serine-type aminopeptidase activity, cysteine-type peptidase activity,
FF_2.40.10.10_37752	Genome polyprotein -like domain 1/2	Potyvirus	22781	serine-type endopeptidase activity, cysteine-type peptidase activity,

Retrieve all sequences

OMIM code	Description	Sequences
276000	PANCREATITIS - HEREDITARY PRSS1 - ARG122HIS - 365G-A RECLASSIFIED - VARIANT OF UNKNOWN SIGNIFICANCE PRSS1 - ALA121THR PANCREATITIS - HEREDITARY PRSS1 - ASN29ILE PANCREATITIS - HEREDITARY PRSS1 - ARG122HIS - 365GC-AT PANCREATITIS - HEREDITARY PRSS1 - ARG122CYS PANCREATITIS - HEREDITARY PRSS1 - ASN54SER PANCREATITIS - HEREDITARY PRSS1 - ARG116CYS PANCREATITIS - HEREDITARY PRSS1 - GLU79LYS	Get Sequences
176930	DYSPROTHROMBINEMIA F2 - ARG382CYS DYSPROTHROMBINEMIA PROTHROMBIN HIMI-II F2 - ARG388HIS DYSPROTHROMBINEMIA F2 - GLY558VAL DYSPROTHROMBINEMIA F2 - ASP552GLU DYSPROTHROMBINEMIA F2 - MET337THR DYSPROTHROMBINEMIA F2 - ARG382HIS DYSPROTHROMBINEMIA F2 - ARG418TRP	Get Sequences
612283	THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL RECESSIVE PROC - LEU223PHE THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL RECESSIVE PROC - PRO247LEU THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL RECESSIVE PROC - ALA259VAL THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL DOMINANT PROC - ARG178TRP THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL DOMINANT PROC - VAL297MET THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL RECESSIVE PROC - GLY301SER THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL RECESSIVE PROC - ALA267THR THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL RECESSIVE PROC - GLY292SER THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL DOMINANT PROC - GLN184HIS THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL DOMINANT PROC - TRP402CYS THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL DOMINANT PROC - SER270LEU THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL DOMINANT PROC - ARG230CYS THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL RECESSIVE PROC - ILE403MET THROMBOPHILIA - HEREDITARY - DUE TO PROTEIN C DEFICIENCY - AUTOSOMAL DOMINANT PROC - ARG178GLN	Get Sequences
264900	FACTOR XI DEFICIENCY F11 - SER576ARG FACTOR XI DEFICIENCY F11 - ALA412VAL FACTOR XI DEFICIENCY F11 - PHE442VAL FACTOR XI DEFICIENCY F11 - GLY400VAL FACTOR XI DEFICIENCY F11 - THR386ASN FACTOR XI DEFICIENCY F11 - TRP569SER	Get Sequences
173350	DYSPLASMINOGENEMIA PLG - GLY732ARG DYSPLASMINOGENEMIA PLG - ALA601THR DYSPLASMINOGENEMIA PLG - SER572PRO	Get Sequences
217030	HEMOLYTIC UREMIC SYNDROME - ATYPICAL - SUSCEPTIBILITY TO - 3 CFI - ASP519ASN	Get Sequences
605511	DEAFNESS - AUTOSOMAL RECESSIVE 10 TMPRSS3 - TRP251CYS DEAFNESS - AUTOSOMAL RECESSIVE 10 DEAFNESS - CHILDHOOD-ONSET NEUROSENSORY - AUTOSOMAL RECESSIVE 8 - INCLUDED TMPRSS3 - PRO404LEU DEAFNESS - AUTOSOMAL RECESSIVE 10 TMPRSS3 - ARG216LEU	Get Sequences
229000	PREKALLIKREIN DEFICIENCY KLKB1 - CYS529TYR	Get Sequences
606441	PARKINSON DISEASE 13 - SUSCEPTIBILITY TO HTRA2 - ALA141SER	Get Sequences
300746	HEMOPHILIA B F9 - THR296MET HEMOPHILIA B F9 - VAL328PHE HEMOPHILIA B(M) F9 - VAL182LEU HEMOPHILIA B F9 - ILE397THR HEMOPHILIA B F9 - CYS206SER HEMOPHILIA B F9 - VAL373GLU HEMOPHILIA B F9 - ILE344THR HEMOPHILIA B F9 - GLY363VAL HEMOPHILIA B F9 - GLY311ARG HEMOPHILIA B F9 - GLY367ARG HEMOPHILIA B F9 - MET348VAL HEMOPHILIA B F9 - CYS350SER HEMOPHILIA B F9 - ALA390GLU HEMOPHILIA B F9 - GLY309VAL HEMOPHILIA B F9 - GLY311GLU HEMOPHILIA B F9 - ALA351PRO HEMOPHILIA B F9 - VAL181PHE HEMOPHILIA B F9 - SER360LEU HEMOPHILIA B F9 - ALA233THR HEMOPHILIA B F9 - VAL307ALA HEMOPHILIA B F9 - ALA291PRO HEMOPHILIA B F9 - PRO287LEU HEMOPHILIA B F9 - PRO368THR HEMOPHILIA B F9 - SER365GLY HEMOPHILIA B F9 - CYS336ARG HEMOPHILIA B F9 - VAL182PHE HEMOPHILIA B F9 - SER365ILE HEMOPHILIA B F9 - CYS222TRP HEMOPHILIA B F9 - PHE378LEU FACTOR IX POLYMORPHISM F9 - HIS257TYR HEMOPHILIA B F9 - TRP407ARG HEMOPHILIA B F9 - ASN260SER HEMOPHILIA B F9 - ARG248GLN HEMOPHILIA B F9 - ARG333GLN HEMOPHILIA B F9 - ARG338PRO HEMOPHILIA B F9 - GLU245VAL HEMOPHILIA B F9 - GLY396ARG THROMBOPHILIA - X-LINKED - DUE TO FACTOR IX DEFECT F9 - ARG338LEU HEMOPHILIA B F9 - ALA390VAL FACTOR IX - DNA POLYMORPHISM F9 - VAL227VAL HEMOPHILIA B F9 - GLN191LEU HEMOPHILIA B F9 - ASP364HIS	Get Sequences
227500	FACTOR VII DEFICIENCY F7 - ALA294VAL MYOCARDIAL INFARCTION - DECREASED SUSCEPTIBILITY TO F7 - ARG353GLN FACTOR VII DEFICIENCY F7 - CYS329GLY FACTOR VII DEFICIENCY F7 - ALA244VAL FACTOR VII MIE F7 - ARG247HIS FACTOR VII DEFICIENCY F7 - CYS310PHE FACTOR VII DEFICIENCY F7 - PHE328SER FACTOR VII DEFICIENCY F7 - THR359MET FACTOR VII DEFICIENCY F7 - HIS348GLN FACTOR VII HARROW FACTOR VII PADUA F7 - ARG304GLN FACTOR VII DEFICIENCY F7 - CYS178TYR FACTOR VII DEFICIENCY F7 - GLY354CYS	Get Sequences
606797	ICHTHYOSIS WITH HYPOTRICHOSIS - AUTOSOMAL RECESSIVE ST14 - GLY827ARG	Get Sequences
134350	COMPLEMENT FACTOR D DEFICIENCY CFD - VAL213GLY AND CYS214ARG	Get Sequences
227600	FACTOR X FRIULI F10 - PRO343SER FACTOR X STOCKTON F10 - ASP282ASN FACTOR X DEFICIENCY F10 - VAL298MET FACTOR X DEFICIENCY F10 - SER334PRO FACTOR X DEFICIENCY - AUTOSOMAL DOMINANT F10 - GLY249ARG FACTOR X DEFICIENCY F10 - ARG287TRP	Get Sequences
602194	CEREBRAL AUTOSOMAL RECESSIVE ARTERIOPATHY WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY HTRA1 - ALA252THR CEREBRAL AUTOSOMAL RECESSIVE ARTERIOPATHY WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY HTRA1 - VAL297MET	Get Sequences
130130	NEUTROPENIA - SEVERE CONGENITAL - AUTOSOMAL DOMINANT 1 ELANE - VAL72MET CYCLIC HEMATOPOIESIS ELANE - ARG191GLN CYCLIC HEMATOPOIESIS ELANE - LEU177PHE NEUTROPENIA - SEVERE CONGENITAL - AUTOSOMAL DOMINANT 1 ELANE - VAL69LEU AND VAL72LEU CYCLIC HEMATOPOIESIS ELANE - ALA32VAL NEUTROPENIA - SEVERE CONGENITAL - AUTOSOMAL DOMINANT 1 ELANE - SER97LEU NEUTROPENIA - SEVERE CONGENITAL - AUTOSOMAL DOMINANT 1 ELANE - CYS42ARG NEUTROPENIA - SEVERE CONGENITAL - AUTOSOMAL DOMINANT 1 ELANE - GLY185ARG NEUTROPENIA - SEVERE CONGENITAL - AUTOSOMAL DOMINANT 1 ELANE - PRO110LEU	Get Sequences
603924	FACTOR VII-ACTIVATING PROTEASE MARBURG I CAROTID STENOSIS - SUSCEPTIBILITY TO - INCLUDED;; VENOUS THROMBOEMBOLISM - SUSCEPTIBILITY TO - INCLUDED HABP2 - GLY534GLU	Get Sequences
140100	ANHAPTOGLOBINEMIA HP - ILE247THR	Get Sequences
610619	FACTOR XII (WASHINGTON D.C.) F12 - CYS571SER	Get Sequences
601564	PANCREATITIS - CHRONIC - PROTECTION AGAINST PRSS2 - GLY191ARG	Get Sequences
601405	PANCREATITIS - CHRONIC - SUSCEPTIBILITY TO CTRC - ARG254TRP	Get Sequences